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A chiral trimethyl lock based on the vicinal disubstituent effect: prolonged release of camptothecin into cancer cells.
- Source :
-
Chemical Communications . 6/28/2024, Vol. 60 Issue 51, p6524-6527. 4p. - Publication Year :
- 2024
-
Abstract
- Synthesis and in vitro testing of a prodrug designed for the controlled delivery of the anticancer drug camptothecin within pancreatic cancer cells are reported. Our study reveals a non-conventional pharmacokinetic release characterized by an exponential pattern before reaching the half-life (t1/2) and a linear pattern thereafter. The release mechanism was triggered either by hydrolytic enzymes and/or by the acid microenvironment of cancer cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 51
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 178005907
- Full Text :
- https://doi.org/10.1039/d4cc01220h