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Dosimetric analysis of six whole-breast irradiation techniques in supine and prone positions.

Authors :
Kim, Dong Wook
Hong, Chae-Seon
Son, Junyoung
Kim, Se Young
Park, Ye-In
Chung, Mijoo
Chung, Weon Kuu
Han, Min Cheol
Kim, Jihun
Kim, Hojin
Kim, Jin Sung
Source :
Scientific Reports. 6/21/2024, Vol. 14 Issue 1, p1-11. 11p.
Publication Year :
2024

Abstract

In breast cancer radiation therapy, minimizing radiation-related risks and toxicity is vital for improving life expectancy. Tailoring radiotherapy techniques and treatment positions can reduce radiation doses to normal organs and mitigate treatment-related toxicity. This study entailed a dosimetric comparison of six different external beam whole-breast irradiation techniques in both supine and prone positions. We selected fourteen breast cancer patients, generating six treatment plans in both positions per patient. We assessed target coverage and organs at risk (OAR) doses to evaluate the impact of treatment techniques and positions. Excess absolute risk was calculated to estimate potential secondary cancer risk in the contralateral breast, ipsilateral lung, and contralateral lung. Additionally, we analyzed the distance between the target volume and OARs (heart and ipsilateral lung) while considering the treatment position. The results indicate that prone positioning lowers lung exposure in X-ray radiotherapy. However, particle beam therapies (PBTs) significantly reduce the dose to the heart and ipsilateral lung regardless of the patient's position. Notably, negligible differences were observed between arc-delivery and static-delivery PBTs in terms of target conformity and OAR sparing. This study provides critical dosimetric evidence to facilitate informed decision-making regarding treatment techniques and positions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20452322
Volume :
14
Issue :
1
Database :
Academic Search Index
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
178028330
Full Text :
https://doi.org/10.1038/s41598-024-65461-y