人工虎骨粉治疗绝经后骨质疏松的临床疗效.

Objective To observe the effect of artificial tiger bone powder on bone mineral density, physical capacity, fall risk, and fracture risk in patients with postmenopausal osteoporosis. Methods One hundred and sixty postmenopausal patients with osteoporosis were divided into control group and experimental group by random number table method, with 80 cases in each group. Patients in the control group received Alfacalciferol capsule+calcic D3 tablets+alendronate sodium tablets. On the basis of this, patients in the experimental group received artificial tiger bone powder capsule for treatment. The data of BMD, MFES, SPPB, fragile fractures, and fall incidence of patients were compared for statistical analysis. Results ①One hundred and fifty-four patients were eventually gathered from the trial, after two patients from the experimental group and four patients from the control group withdrew during the study; ②BMD: following a 12-month course of treatment, baseline BMD showed improvement both in the experimental and in the control group, and the difference was statistically significant (P<0.05). The BMD improvement in the experimental group was greater than that in the control group, and the difference was also statistically significant (P<0.05); ③SPPB: The experimental group showed a statistically significant difference between baseline and 6 and 12 months of treatment (P<0.05). The control group also showed a statistically significant difference after 12 months of treatment (P<0.05). The experimental group also performed better on the SPPB after 12 months of treatment than the control group, with the difference being statistically significant (P<0.05); ④MFES: the comparison between the two groups showed that the MFES of the experimental group was better than that of the control group after 6 and 12 months of treatment, with a statistically significant difference (P<0.05). The difference between the experimental group and the control group after 12 months of treatment and before treatment was also statistically significant (P<0.05);⑤ Incidence of falls and fractures: The falls in the experimental group were 24 times, and the incidence of falls was 30.77%. The falls in the control group were 35 times, and the incidence of fall was 46.05%. The fractures in the experimental group were 4 times, and the fracture rate was 5.13%. The fractures in the control group were 6 times, and the fracture rate was 7.89%. Conclusion The artificial tiger bone powder effectively improves bone mineral density, physical activity, reduces the risk of fall, and reduces the incidence of fractures. The effect is better than that of simple triple drug. [ABSTRACT FROM AUTHOR]