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NFKB1 variants were associated with the risk of Parkinson´s disease in male.

Authors :
Perez-Oliveira, Sergio
Vazquez-Coto, Daniel
Pardo, Sara
Blázquez-Estrada, Marta
Menéndez-González, Manuel
Siso, Pablo
Suárez, Esther
García-Fernández, Ciara
Fages, Beatriz de la Casa
Coto, Eliecer
Álvarez, Victoria
Source :
Journal of Neural Transmission. Jul2024, Vol. 131 Issue 7, p773-779. 7p.
Publication Year :
2024

Abstract

The NF-κB pathway is involved in the pathogenesis of neurological disorders that have inflammation as a hallmark, including Parkinson's disease (PD). Our objective was to determine whether common functional variants in the NFKB1, NFKBIA and NFKBIZ genes were associated with the risk of PD. A total of 532 Spanish PD cases (61% male; 38% early-onset, ≤ 55 years) and 300 population controls (50% ≤55 years) were genotyped for the NFKB1 rs28362491 and rs7667496, NFKBIA rs696, and NFKBIZ rs1398608 polymorphisms. We compared allele and genotype frequencies between early and late-onset, male and female, and patient's vs. controls. We found that the two NFKB1 alleles were significantly associated with PD in our population (p = 0.01; total patients vs. controls), without difference between Early and Late onset patients. The frequencies of the NFKB1 variants significantly differ between male and female patients. Compared to controls, male patients showed a significantly higher frequency of rs28362491 II (p = 0.02, OR = 1.52, 95%CI = 1.10–2.08) and rs28362491 C (p = 0.003, OR = 1.62, 95%CI = 1.18–2.22). The two NFKB1 variants were in strong linkage disequilibrium and the I-C haplotype was significantly associated with the risk of PD among male (p = 0.002). In conclusion, common variants in the NF-kB genes were associated with the risk of developing PD in our population, with significant differences between male and female. These results encourage further studies to determine the involvement of the NF-kB components in the pathogenesis of Parkinson´s disease. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03009564
Volume :
131
Issue :
7
Database :
Academic Search Index
Journal :
Journal of Neural Transmission
Publication Type :
Academic Journal
Accession number :
178065606
Full Text :
https://doi.org/10.1007/s00702-024-02759-1