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Feasibility of continued treatment with dupilumab in patients with type 2 inflammatory disease who developed eosinophilic pneumonia: 3 case reports.

Authors :
Hamakawa, Masamitsu
Tanaka, Ayaka
Tokioka, Fumiaki
Ishida, Tadashi
Source :
Respirology Case Reports. Jun2024, Vol. 12 Issue 6, p1-6. 6p.
Publication Year :
2024

Abstract

Several reports have described dupilumab‐induced eosinophilic pneumonia (EP) after treatment with dupilumab in patients with type 2 inflammatory disease. Other reports have suggested the efficacy of dupilumab for chronic EP (CEP). Whether dupilumab can be continued in patients with type 2 inflammatory disease who develop EP during dupilumab treatment remains unclear. We present herein three cases with different clinical presentations involving dupilumab and EP. In Case 1, dupilumab was discontinued because of dupilumab‐induced EP during the treatment of asthma. In Case 2, although pre‐existing idiopathic EP worsened during the treatment of eosinophilic chronic rhinosinusitis (ECRS), dupilumab was continued. In Case 3, CEP and ECRS were successfully treated with dupilumab and corticosteroids were discontinued. In conclusion, treatment with dupilumab in patients with type 2 inflammatory disease and idiopathic EP is worth considering if the benefits are deemed to outweigh the risks and careful attention is given to the clinical course. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20513380
Volume :
12
Issue :
6
Database :
Academic Search Index
Journal :
Respirology Case Reports
Publication Type :
Academic Journal
Accession number :
178071846
Full Text :
https://doi.org/10.1002/rcr2.1412