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Oral administration of herbal oligonucleotide drug JGL‐sRNA‐h7 ameliorates hyperglycemia in db/db mice and beagle dogs.
- Source :
-
IUBMB Life . Jun2024, p1. 9p. 5 Illustrations. - Publication Year :
- 2024
-
Abstract
- Type 2 diabetes mellitus is a prevalent metabolic disease, posing a considerable threat to public health. Oligonucleotide drugs have proven to be a promising field of therapy for the diseases. In this study, we reported that a herbal small RNA (sRNA), JGL‐sRNA‐h7 (B34735529, F1439.L002444.A11), could exhibit potent hypoglycemic effects by targeting glucose‐6‐phosphatase. Oral administration of sphingosine (d18:1)‐JGL‐sRNA‐h7 bencaosomes ameliorated hyperglycemia and diabetic kidney injury better than metformin in db/db mice. Furthermore, glucose tolerance was also improved in sphingosine (d18:1)‐JGL‐sRNA‐h7 bencaosomes‐treated beagle dogs. Our study indicates that JGL‐sRNA‐h7 could be a promising hypoglycemic oligonucleotide drug. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BEAGLE (Dog breed)
*ORAL drug administration
*TYPE 2 diabetes
*NON-coding RNA
Subjects
Details
- Language :
- English
- ISSN :
- 15216543
- Database :
- Academic Search Index
- Journal :
- IUBMB Life
- Publication Type :
- Academic Journal
- Accession number :
- 178083464
- Full Text :
- https://doi.org/10.1002/iub.2859