Intertrigo en pacientes hospitalizados en el servicio de Medicina Interna de un hospital de la Ciudad de México. Causa fúngica y sensibilidad antifúngica in vitro.

OBJECTIVES: To determine the frequency of fungi causing intertrigo in patients hospitalized and to evaluate the in vitro activity of fluconazole, itraconazole, amorolfine and cetrimonium bromide on the fungal isolates. MATERIALS AND METHODS: An observational, prospective and cross-sectional study, done in the Internal Medicine Service of the General Hospital Dr. Dario Fernandez Fierro, ISSSTE, Mexico City, from July 1st 2018 to June 30th 2019, in which fungal isolates were obtained from intertrigo patients and identified by phenotypic and biochemical methods. Antifungal susceptibility testing was performed by broth microdilution method. RESULTS: Out of 359 patients hospitalized at the Internal Medicine Department during a year, 21 (5.8%) had intertrigo in several anatomical folds and in 14 a fungal etiology was demonstrated. The most affected folds were inguinal and submammary. The main fungi causing intertrigo were Candida albicans and Candida glabrata. In general, fluconazole and itraconazole showed good antifungal activity in all isolates. One of the C. albicans isolates showed resistance to itraconazole, amorolfine and fluconazole. Amorolfine showed no activity against five of the C. albicans isolates. CONCLUSIONS: This study shows the importance of identifying and determining the antifungal susceptibility of the fungi causing intertrigo in patients with multiple risk factors to achieve a successful treatment. [ABSTRACT FROM AUTHOR]