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Effects of exercise training with intermittent hyperoxic intervention on endurance performance and muscle metabolic properties in male mice.
- Source :
-
Physiological Reports . Jun2024, Vol. 12 Issue 12, p1-17. 17p. - Publication Year :
- 2024
-
Abstract
- This study aimed to investigate how intermittent hyperoxic exposure (three cycles of 21% O2 [10 min] and 30% O2 [15 min]) affects exercise performance in mice. Three hours after the acute exposure, there was an observed increase in mRNA levels of phosphofructokinase (Bayes factor [BF] ≥ 10), mitochondrial transcription factor‐A (BF ≥10), PPAR‐α (BF ≥3), and PPAR‐γ (BF ≥3) in the red gastrocnemius muscle (Gr). Four weeks of exercise training under intermittent (INT), but not continuous (HYP), hyperoxia significantly (BF ≥30) increased maximal exercise capacity compared to normoxic exercise‐trained (ET) group. INT group exhibited significantly higher activity levels of 3‐hydroxyacyl‐CoA‐dehydrogenase (HAD) in Gr (BF = 7.9) compared to ET group. Pyruvate dehydrogenase complex activity levels were significantly higher in INT group compared to ET group in white gastrocnemius, diaphragm, and left ventricle (BF ≥3). NT‐PGC1α protein levels in Gr (BF = 7.7) and HAD activity levels in Gr (BF = 6.9) and soleus muscles (BF = 3.3) showed a significant positive correlation with maximal work values. These findings suggest that exercise training under intermittent hyperoxia is a beneficial strategy for enhancing endurance performance by improving fatty acid and pyruvic acid utilization. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2051817X
- Volume :
- 12
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Physiological Reports
- Publication Type :
- Academic Journal
- Accession number :
- 178131771
- Full Text :
- https://doi.org/10.14814/phy2.16117