One-Pot N -α-C(sp3)– H Bond Functionalisation Cascade for the Synthesis of Polysubstituted Imidazoles.

This article presents a new method for synthesizing polysubstituted imidazoles, which are compounds with various pharmaceutical and biological applications. The authors optimized the reaction conditions using iron catalysis and oxygen as the sole oxidant, resulting in high yields of the desired products. The protocol provides a straightforward and efficient method for synthesizing polysubstituted imidazole compounds using easily available starting materials. The article also includes chemical data for various compounds, including their yields, physical properties, and nuclear magnetic resonance (NMR) spectra. [Extracted from the article]