Organ-specific vasculature-on-a-chip systems.

The article discusses the importance of understanding organ-specific vasculature and its implications for tissue-specific vascular therapies and bioengineering human organs. It highlights recent advances in microfabrication techniques and organ-on-a-chip systems that allow for the study of tissue-specific blood and lymphatic vasculature in a physiologically relevant context. The article also explores the use of vascularized organ-on-a-chip systems for studying host-bacteria interactions and cellular responses related to bacterial infections. Additionally, it presents microfluidic platforms that enable the investigation of how the liver endothelium changes in response to its microenvironment and how the liver responds to changes in the endothelium. The article concludes by emphasizing the potential of these models to improve drug development and investigate organ-specific cancer metastasis. [Extracted from the article]