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The Effect of Isotretinoin on Insulin Resistance and Serum Adiponectin Levels in Acne Vulgaris Patients: A Systematic Review and Meta-Analysis.
- Source :
-
Clinics & Practice . Jun2024, Vol. 14 Issue 3, p1021-1037. 17p. - Publication Year :
- 2024
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Abstract
- Background: Isotretinoin is the drug of choice for severe acne. We sought to examine the potential link between isotretinoin and insulin resistance. Methods: We conducted a systematic review and meta-analysis in accordance with the PRISMA statement. A comprehensive search of the PubMed/MEDLINE, SCOPUS, and Cochrane databases was performed until 12 January 2022 utilizing the PICO (Patient, Intervention, Comparison, Outcome) tool. Fifteen English-language studies focusing on isotretinoin-treated acne patients were included. Serum levels of insulin, glucose, and adiponectin were evaluated before and after treatment, and insulin sensitivity was assessed using the HOMA–IR. A meta-analysis was conducted using RevMan 5.4.1 software, and a quality assessment was undertaken using the ROBINS-I tool. Results: The meta-analysis unveiled a statistically significant rise in the post-treatment levels of adiponectin, an anti-inflammatory agent, which inhibits liver glucose production while enhancing insulin sensitivity (SMD = 0.86; 95% confidence interval (95% CI) = 0.48–1.25, p-value < 0.0001; I2 = 58%). Our subgroup analysis based on study type yielded consistent findings. However, no statistically significant outcomes were observed for insulin, glucose levels, and the HOMA-IR. Conclusions: There is not a clear association between isotretinoin and insulin resistance, but it appears to enhance the serum levels of adiponectin, which participates in glucose metabolism. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INSULIN resistance
*ACNE
*ADIPONECTIN
*ISOTRETINOIN
*INSULIN sensitivity
Subjects
Details
- Language :
- English
- ISSN :
- 20397283
- Volume :
- 14
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinics & Practice
- Publication Type :
- Academic Journal
- Accession number :
- 178152915
- Full Text :
- https://doi.org/10.3390/clinpract14030081