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The ‘fully protected backbone’ approach as a versatile tool for a new solid-phase PNA synthesis strategy
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Jun2005, Vol. 46 Issue 23, p4081-4085. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: The ‘fully protected backbone’ (FPB) strategy has been efficiently adapted to the solid-phase synthesis of homothymine, homocytosine and ‘mixed’ pyrimidine PNAs. This versatile and simple method avoids the preparation of PNA monomers and relies on easy available starting materials, highly efficient backbone elongations and effective nucleobase units condensations. [Copyright &y& Elsevier]
- Subjects :
- *MONOMERS
*MOLECULES
*THYMINE
*PYRIMIDINES
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 46
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17822819
- Full Text :
- https://doi.org/10.1016/j.tetlet.2005.04.018