Cell type-specific polygenic burden modulates exercise effects in schizophrenia patients: further evidence on volumes of hippocampal subfields.

This article explores the relationship between physical activity and clinical outcomes in patients with schizophrenia. It highlights previous research showing that aerobic exercise can improve symptoms in schizophrenia patients by increasing hippocampal volume. However, the study also suggests that not all patients respond the same way to physical activity, and genetic factors may play a role. Specifically, patients with a larger genetic burden may experience a decrease in hippocampal volume after aerobic exercise. The study emphasizes the importance of considering genetic factors and the type and intensity of physical activity when examining the impact on brain volumetric changes. However, due to the small sample size, further research is needed to confirm these findings in larger cohorts. The study was supported by the German Federal Ministry of Education and Research and the German Center for Mental Health, and the authors have no competing interests. [Extracted from the article]