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Relationship between fortilin levels and coronary ischemia in heart failure.
- Source :
-
European Research Journal . Jul2024, Vol. 10 Issue 4, p338-344. 7p. - Publication Year :
- 2024
-
Abstract
- Objectives: Fortilin is a multifunctional protein that protects cells against apoptosis. We aimed to investigate the levels of fortilin in patients with heart failure. Methods: Patients with ejection fraction (EF) below 40% were divided into two groups according to coronary angiography results: those with ischemic heart failure (Group 1) and those with non-ischemic heart failure (Group 2). Patients with normal anatomy and EF over 50% were included in the control group (Group 3). Results: A total of 119 patients were prospectively included in the study. A total of 81 patients (41 patients with ischemic heart failure and 40 patients with non-ischemic heart failure) were included in the heart failure group. 38 patients with EF >50 and normal coronary anatomy were included in the control group. There was no significant difference in serum fortilin levels between the study groups (Group 1: 5.5 ± 2.6 ng/mL, Group 2: 6.1 ± 3.8 ng/mL, and Group 3: 5.6 ± 3.6 ng/mL; P=0.693). Fortilin did not show a correlation with any other variables. Conclusion: In our study, there was no significant difference in fortilin levels between the groups, and no relationship was found between coronary ischemia and fortilin levels in heart failure. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEART failure
*PROTEIN structure
*HEART disease diagnosis
*CORONARY angiography
Subjects
Details
- Language :
- English
- ISSN :
- 21493189
- Volume :
- 10
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Research Journal
- Publication Type :
- Academic Journal
- Accession number :
- 178289834
- Full Text :
- https://doi.org/10.18621/eurj.1447544