超重/肥胖与血脂异常的交互作用 对高尿酸血症的影响.

Objective To investigate the interaction between overweight/obesity and dyslipidemia on hyperuricemia (HUA), and to provide scientific basis for the prevention and treatment of HUA. Methods The data were derived from the physical examination records of workers at the Xishan Coal and Electricity Group in 2018, encompassing a total of 38 615 study participants. SAS 9. 3 software was used to conduct 咒2 test and multivariate logistic regression analyses. Additive interaction model was used to analyze the interaction between overweight/obesity and dyslipidemia on HUA. Results The prevalence rate of HUA was 18.28%. After adjusting for gender, age, smoking, drinkings systolic blood pressure, diastolic blood pressure, fasting blood glucose and blood creatinine, the results of multivariate logistic regression analyses showed that overweight/obesity (OR - 2. 756, 95% Cl: 2, 584 - 2. 939) and dyslipidemia (OR = 2, 221, 95% Cl: 2. 100 - 2. 349) were associated with a higher risk of HUA, respectively. Interaction analyses showed a synergistic additive interaction between overweight/obesity and dyslipidemia on the prevalence of HUA, with those who were overweight/obese and dyslipidemic having a higher risk of HUA than those who had neither (OR =4. 840,95% CI: 4.452 - 5. 261), and the relative excess risk of interaction (RERI) was 0.4, the attributable proportion of interaction (API) was 0.083, and the synergy index (SI) was 1. 116. Conclusion Overweight/obesity and dyslipidemia both increase the risk of HUA, and there is synergistic additive interaction between them. Controlling body mass index and lipid levels may prevent HUA.. [ABSTRACT FROM AUTHOR]