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Bispecific BCMA/CD19 targeted CAR-T cell therapy forces sustained disappearance of symptoms and anti-acetylcholine receptor antibodies in refractory myasthenia gravis: a case report.

Authors :
Zhang, Yong
Liu, Dan
Zhang, Zhouao
Huang, Xiaoyu
Cao, Jiang
Wang, Gang
Du, Xue
Wang, Zhouyi
Yang, Mingjin
Luo, Tiancheng
liu, Sha
Zhang, Wan
Sheng, Ying
Li, Huizhong
Zhang, Wei
Chen, Hao
Zhang, Shenyang
Wang, Xiaopeng
Meng, Wenqing
Zong, Shenghua
Source :
Journal of Neurology. Jul2024, Vol. 271 Issue 7, p4655-4659. 5p.
Publication Year :
2024

Abstract

This article discusses a case report on the use of bispecific CAR-T cell therapy in a patient with refractory myasthenia gravis (MG), an autoimmune neuromuscular disorder. The patient experienced sustained disappearance of symptoms and anti-acetylcholine receptor antibodies after receiving the therapy. The study suggests that bispecific CAR-T cell therapy has the potential to be an effective treatment for MG and other diseases characterized by autoreactive B cells and autoantibodies. [Extracted from the article]

Details

Language :
English
ISSN :
03405354
Volume :
271
Issue :
7
Database :
Academic Search Index
Journal :
Journal of Neurology
Publication Type :
Academic Journal
Accession number :
178340963
Full Text :
https://doi.org/10.1007/s00415-024-12367-4