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Highlight of 2023: Virtues and vices of CD4 CAR T cells.
- Source :
-
Immunology & Cell Biology . Jul2024, Vol. 102 Issue 6, p432-436. 5p. - Publication Year :
- 2024
-
Abstract
- This article discusses recent research on CD4 CAR T cells and their role in CAR T cell therapy (CTT). CD4 CAR T cells have traditionally been seen as providing support to CD8 CAR T cells, but recent studies have shown that CD4 CAR T cells can directly kill tumor cells and control their growth. However, CD4 CAR T cells have also been found to contribute to cytokine release syndrome (CRS), a serious adverse event in CTT. The article highlights the need for a deeper understanding of the roles and mechanisms of CD4 CAR T cells in order to design safer and more effective CAR T cell products. Additionally, the article discusses the impact of CD4 T cells on CAR T cell manufacturing, suggesting that co-culturing CD4 T cells with CD8 T cells can improve the quantity and quality of CAR T cells. The article concludes by emphasizing the importance of leveraging the benefits of CD4 T cells while minimizing their negative effects in CTT. [Extracted from the article]
- Subjects :
- *T cells
*CD4 antigen
*CYTOTOXIC T cells
*T cell receptors
Subjects
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 102
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 178355921
- Full Text :
- https://doi.org/10.1111/imcb.12764