LITERATURE REVIEW: POTENSIAL EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM) SEBAGAI OBAT ANTI-TUBERKULOSIS.

Tuberculosis (TB) is widely known as a highly contagious infectious disease in the world. Pulmonary tuberculosis (TB) is a common global health problem, causing many people to become infected each year. Indonesia occupies the second largest contributor to death from this disease worldwide, after HIV-AIDS. Every year, TB claims the lives of 1.5 million people worldwide. Currently, India is ranked second globally in terms of the number of people affected by tuberculosis, after India itself. This information comes from a 2020 report published by WHO. The global incidence of tuberculosis in 2020 amounted to 10 million cases and resulted in 1.2 million deaths globally. In 2020, Indonesia reported a total of 824,000 cases which was further exacerbated by the start of the Covid-19 virus pandemic. Garlic is a plant that has various biological properties, including antibacterial, anticancer, antioxidant, immunomodulatory, anti-inflammatory, hypoglycemic, and cardiovascular effects. The purpose of this study was to assess the efficacy of garlic extract (Allium sativum) in inhibiting the proliferation of Mycobacterium tuberculosa. Researchers conducted a literature search using Google Scholar, NCBI, and sciencedirect.com using the keywords Mycobacterium tuberculosa, garlic, and Allium sativum. Furthermore, a total of six papers that met the predetermined inclusion criteria were examined. Garlic, a recognized antimicrobial agent, was used in the study to combat Mycobacterium tuberculosa. Garlic is known for its inherent antimicrobial properties. Allicin is a bioactive compound found in garlic that exhibits antibacterial properties. Allicin, a chemical found in garlic (Allium sativum Linn), has antibacterial properties that can effectively inhibit tuberculosis-causing germs. [ABSTRACT FROM AUTHOR]