Systematic and Therapeutic Applications to Understand the Mechanisms of Drug Resistance in Pediatric Acute Myeloid Leukemia through Network Pharmacology.

Studies have shown that natural flavone and flavonoids are molecules derived from the natural source and can selectively kill certain cancer cells. However, the exact process by which these bioactive substances affect acute myeloid leukemia is still unknown. To further understand about the medication resistance and find possible treatments for pediatric acute myeloid leukemia, we used network pharmacology methods. We specifically examined the pharmacological impacts of polyphenols, particularly kaempferol, catechin and quercetin on the treatment of acute myeloid leukemia. Using public databases including PubChem, Kyoto Encyclopedia of Genes and Genomes Mapper, Universal Protein Resource, DisGenet and cystoscope databases, we conducted a thorough search for the potential targets of polyphenols and acute myeloid leukemia. Consequently, we identified polyphenol target genes and acute myeloid leukemia disease targets. Among the 253 genes showed overlapping; however, some might be potential as polyphenol-based acute myeloid leukemia therapy targets. The specific method by which these bioactive substances exert their anti-acute myeloid leukemia effects has been elucidated through the use of protein-protein interaction network analysis, gene ontology analysis and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analysis. Further cytological examinations confirmed these results, illustrating the polyphenol's capacity to hinder the growth of acute myeloid leukemia cells through different pathways. Our study combines network pharmacology-based predictions with systematic review studies for polyphenolic-mediated therapy of acute myeloid leukemia. This provides new perspectives on therapeutic approaches to address drug resistance in pediatric acute myeloid leukemia. [ABSTRACT FROM AUTHOR]