变频相位干涉电场刺激对运动皮层兴奋性及运动学习表现的影响.

Objective: To investigate the effects of temporal interference electrical fields (TI) on motor cortical excitability and motor learning abilities in healthy adults, in order to provide evidence for the application of TI stimulation in human. Method: A randomized crossover double-blind design was used with healthy adults participants. Experiment 1: twenty subjects completed transcranial magnetic stimulation (TMS) testing to assess changes in cortical excitability indicators before and after stimulation, including motor evoked potentials (MEP), resting motor threshold (RMT), short- interval intracortical inhibition (SICI), and intracortical facilitation (ICF). Experiment 2: sixteen subjects completed the random reaction time task (RRTT) and the serial reaction time task (SRTT), with performance indicators including average reaction time (RT), first implicit learning (FIL), and second implicit learning (SIL). The effects of TI stimulation on cortical excitability and motor learning abilities were evaluated using a two-factor repeated measures analysis of variance. Result: Experiment 1: there were significant interactions between stimulation condition and time on MEP (F= 28.787, P<0.001, ηP²=0.602) and RMT (F=23.524, P<0.001, ηP²=0.580), while SICI and ICF showed no significant interaction effects. Experiment 2: compared to sham stimulation, FIL in SRTT was significantly improved after TI stimulation (F=4.601, P=0.049, ηP²=0.235), while there was no significant interaction effect in the RRTT task. Conclusion: Variable frequency TI stimulation can significantly increase cortical excitability in the primary motor cortex, and this regulatory effect may contribute to enhancing motor learning performance in healthy adults. [ABSTRACT FROM AUTHOR]