Chapter Seven - African medicinal plants and their constituents can fight glioblastoma and its drug resistance.

Glioblastoma (GBM) is the most common and most aggressive primary brain tumor. In this document, data on the cytotoxicity of plant products from the flora of Africa against drug sensitive and multidrug-resistant (MDR) GBM cell lines were collected from various scientific databases including PubMed, ScienceDirect, Scopus, Web of Science, and Scholar Google. As a result, the cytotoxicity of 42 botanicals and 112 cytotoxic phytochemicals are reported. They were further compiled and ranked following rationally established cut-off values for cytotoxic products from natural sources, to identify the potential phytomedicine. The crude extracts from Vepris soyauxii, Albizia adianthifolia, Curcuma longa, Piper capense, Anonidium mannii, and Uapaca togoensis were identified as the most suitable to combat the drug resistance GBM cells. Compounds identified as the most suitable to fight the multidrug resistance of GBM were isotetrandrine (5), aridanin (11), 7,7″-di-O-methylchamaejasmin (12), isoxanthochymol (13), and canniflavone (14), guieranone A (15), guttiferone E (16), isogarcinol (17), epunctanone (21), hydnocarpin (23), soyauxinium chloride (25), arborinine (27), 5,7-dihydroxy-4′-methoxy-6,8-diprenylisoflavone (28), licarin A (30) and B (31), and bidwillon A (32). These natural products deserve further investigations to produce novel naturally based medicine to combat glioblastoma, including the MDR phenotypes. [ABSTRACT FROM AUTHOR]