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Different Neutralizing Antibody Responses of Heterologous Sera on Sheeppox and Lumpy Skin Disease Viruses.

Authors :
Berguido, Francisco J.
Kangethe, Richard Thiga
Shell, Wendy
Wijewardana, Viskam
Grabherr, Reingard
Cattoli, Giovanni
Lamien, Charles Euloge
Source :
Viruses (1999-4915). Jul2024, Vol. 16 Issue 7, p1127. 8p.
Publication Year :
2024

Abstract

Sheeppox virus (SPPV), goatpox virus (GTPV), and lumpy skin disease virus (LSDV) are the three members of the genus Capripoxvirus within the Poxviridae family and are the etiologic agents of sheeppox (SPP), goatpox (GTP), and lumpy skin disease (LSD), respectively. LSD, GTP, and SPP are endemic in Africa and Asia, causing severe disease outbreaks with significant economic losses in livestock. Incursions of SPP and LSD have occurred in Europe. Vaccination with live attenuated homologous and heterologous viruses are routinely implemented to control these diseases. Using the gold standard virus neutralization test, we studied the ability of homologous and heterologous sera to neutralize the SPPV and LSDV. We found that LSD and SPP sera effectively neutralize their homologous viruses, and GTP sera can neutralize SPPV. However, while LSD sera effectively neutralizes SPPV, SPP and GTP sera cannot neutralize the LSDV to the same extent. We discuss the implications of these observations in disease assay methodology and heterologous vaccine efficacy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19994915
Volume :
16
Issue :
7
Database :
Academic Search Index
Journal :
Viruses (1999-4915)
Publication Type :
Academic Journal
Accession number :
178697757
Full Text :
https://doi.org/10.3390/v16071127