帕金森病脑深部电刺激术后电极错位修正 2 例报道及 文献回顾.

Objective To study the influencing factors, precautions and curative effect of the revision surgeries correcting electrode malposition in deep brain stimulation(DBS)in Parkinson's disease (PD) patients of low improvements after initial DBS therapy. Methods The clinical and imaging date at the same time the process and results of the retarget and reimplant surgeries of 2 patients who were admitted in Second Affiliated Hospital of Shenzhen University from September 2020 to April 2021 after initial DBS therapy were analyzed retrospectively, and the related literature were reviewed. Results In NO. 1 patient, the stimulation target were changed from bilateral subthalamic nucleus (STN) to bilateral GPi, the UPDRS score improvement rate increased 32. 1％in off medication period and 46. 4％in the on phase. NO. 2 patient was reimplanted with left STN, the UPDRS score improvement rate increased 21. 4％in off medication period and 35. 7％in the on phase. Conclusion Lead revision surgery could be a safe and effective remedy for the patients with suboptimal outcomes due to electrode malposition after initial DBS therapy. [ABSTRACT FROM AUTHOR]