Back to Search
Start Over
Three-component cascade carbopalladation/Heck cyclization/borylation: facile access to boryl-functionalized indenes.
- Source :
-
Chemical Communications . 8/11/2024, Vol. 60 Issue 62, p8075-8078. 4p. - Publication Year :
- 2024
-
Abstract
- A mild Pd-catalyzed three-component cascade cyclization functionalization of o-iodostyrenes, internal alkynes and boron reagents is presented. The transformation is driven by a controlled reaction sequence of intermolecular carbopalladation, intramolecular Heck-type cyclization, and a borylation process to give versatile boryl-functionalized indene skeletons in a selective fashion. Significantly, (Bpin)2, (Bneop)2 and CH2(Bpin)2 as boron sources are all tolerated. Additionally, the synthetic utility of this approach is demonstrated by gram-scale synthesis and synthetic transformations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INDENE
*BORYLATION
*ALKYNES
*BORON
*SKELETON
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 62
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 178719263
- Full Text :
- https://doi.org/10.1039/d4cc02591a