Children with elevated wheat IgG4 antibody titer in autism spectrum disorder: Clinical presentation and findings associated with gut microbiota.

This article examines the connection between elevated wheat IgG4 antibody levels and autism spectrum disorder (ASD) in children. The study discovered that children with ASD and high levels of wheat IgG4 antibodies had changes in their gut microbiota and were more susceptible to certain pathogens. These children also experienced alterations in gut microbial carbohydrate-activating enzymes, which impacted their ability to metabolize dietary fiber. These findings suggest a potential relationship between food hypersensitivities, gut microbiota, and ASD. The document discusses the results of a study on the association between food-specific IgG4 antibodies and intestinal infections in children with ASD. The study found that increased IgG4 levels for foods like wheat, milk, yogurt, sheep milk, and eggs were linked to a higher presence of E. coli in fecal samples. The researchers propose that targeting individuals with high levels of food-specific IgG4 antibodies may be more effective in developing dietary interventions for children with ASD. Further research is planned to investigate the presence of immune complexes in the intestinal mucosa. [Extracted from the article]