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Equal levels of pre- and postsynaptic potentiation produce unequal outcomes.

Authors :
Savtchenko, Leonid P.
Rusakov, Dmitri A.
Source :
Philosophical Transactions of the Royal Society B: Biological Sciences. 7/29/2024, Vol. 379 Issue 1906, p1-8. 8p.
Publication Year :
2024

Abstract

Which proportion of the long-term potentiation (LTP) expressed in the bulk of excitatory synapses is postsynaptic and which presynaptic remains debatable. To understand better the possible impact of either LTP form, we explored a realistic model of a CA1 pyramidal cell equipped with known membrane mechanisms and multiple, stochastic excitatory axo-spinous synapses. Our simulations were designed to establish an input–output transfer function, the dependence between the frequency of presynaptic action potentials triggering probabilistic synaptic discharges and the average frequency of postsynaptic spiking. We found that, within the typical physiological range, potentiation of the postsynaptic current results in a greater overall output than an equivalent increase in presynaptic release probability. This difference grows stronger at lower input frequencies and lower release probabilities. Simulations with a non-hierarchical circular network of principal neurons indicated that equal increases in either synaptic fidelity or synaptic strength of individual connections also produce distinct changes in network activity, although the network phenomenology is likely to be complex. These observations should help to interpret the machinery of LTP phenomena documented in situ. This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09628436
Volume :
379
Issue :
1906
Database :
Academic Search Index
Journal :
Philosophical Transactions of the Royal Society B: Biological Sciences
Publication Type :
Academic Journal
Accession number :
178788025
Full Text :
https://doi.org/10.1098/rstb.2023.0235