Back to Search Start Over

Prognosis and treatment in acute myeloid leukemia: a comprehensive review.

Authors :
Debnath, Ankita
Nath, Sukanta
Source :
Egyptian Journal of Medical Human Genetics. 8/6/2024, Vol. 25 Issue 1, p1-15. 15p.
Publication Year :
2024

Abstract

Acute myeloid leukemia (AML) is a heterogeneous disorder that is characterized by clonal expansion of immature "blast cells" in the bone marrow and peripheral circulation, resulting in bone marrow failure and inefficient erythropoiesis. The identification of numerous recurrent genetic mutations such as NPM1, CEBPA, and FLT3-ITD has stratified AML into favorable, intermediate, and adverse-risk groups, respectively, along with a cytogenetic profile that carries a considerably different prognosis among these groups. For post-induction treatment, cytogenetics and genetic mutation testing continue to be vital prognostic tools. Despite advancements, including an increased understanding of biology and new drug targets, the cornerstone of treatment still consists of a combination of cytarabine- and anthracycline-based regimens. The majority of patients eventually relapse and die of the disease, especially the elderly population. This review describes the prognosis of different molecular markers and the major recent advancements in the treatment of AML. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11108630
Volume :
25
Issue :
1
Database :
Academic Search Index
Journal :
Egyptian Journal of Medical Human Genetics
Publication Type :
Academic Journal
Accession number :
178856762
Full Text :
https://doi.org/10.1186/s43042-024-00563-w