To plan efficacious epilepsy surgery.

This article discusses the objective of epilepsy surgery, which is to render a patient seizure-free with minimal resection/ablation to minimize morbidity. The current standard of care involves electroclinical delineation of the seizure onset zone (SOZ) using various diagnostic tools. However, this process is time-consuming, costly, and often inconclusive. The article explores the use of interictal high-frequency oscillations (HFOs) as biomarkers to improve the planning of epilepsy surgery. While some studies have shown strong correlations between HFOs and post-operative seizure outcomes, there are concerns about the reliability of using HFO metrics alone to define resection boundaries. The authors encourage further research and propose a clinical trial to compare the efficacy of the standard resection with resection boundaries amended by HFO metrics. [Extracted from the article]