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Brain-Heart Axis and the Inflammatory Response: Connecting Stroke and Cardiac Dysfunction.

Authors :
Chen, Xiaosheng
Gu, Jiajie
Zhang, Xiaojia
Source :
Cardiology. 2024, Vol. 149 Issue 4, p369-382. 14p.
Publication Year :
2024

Abstract

Background: In recent years, the mechanistic interaction between the brain and heart has been explored in detail, which explains the effects of brain injuries on the heart and those of cardiac dysfunction on the brain. Brain injuries are the predominant cause of post-stroke deaths, and cardiac dysfunction is the second leading cause of mortality after stroke onset. Summary: Several studies have reported the association between brain injuries and cardiac dysfunction. Therefore, it is necessary to study the influence on the heart post-stroke to understand the underlying mechanisms of stroke and cardiac dysfunction. This review focuses on the mechanisms and the effects of cardiac dysfunction after the onset of stroke (ischemic or hemorrhagic stroke). Key Messages: The role of the site of stroke and the underlying mechanisms of the brain-heart axis after stroke onset, including the hypothalamic-pituitary-adrenal axis, inflammatory and immune responses, brain-multi-organ axis, are discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00086312
Volume :
149
Issue :
4
Database :
Academic Search Index
Journal :
Cardiology
Publication Type :
Academic Journal
Accession number :
178911118
Full Text :
https://doi.org/10.1159/000538409