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Millettia dubia De Wild. (Fabaceae): Structural analysis of the oleanane-type glycosides and stimulation of the sweet taste receptors TAS1R2/TAS1R3.
- Source :
-
Phytochemistry . Oct2024, Vol. 226, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- From the root barks of a Central African tree Millettia dubia De Wild. (Fabaceae), ten previously undescribed oleanane-type glycosides were isolated by various chromatographic protocols. Their structures were elucidated by spectroscopic methods, mainly 2D NMR experiments and mass spectrometry, as mono- and bidesmosidic glycosides of mesembryanthemoidigenic acid, hederagenin and oleanolic acid. The stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated, and structure/activity relationships were proposed. Two of them showed an agonist effect on TAS1R2/TAS1R3. [Display omitted] • Ten different oleanolic acid glycosides were isolated. • Their structures were elucidated by extensive 2D NMR analyses. • The stimulation of the sweet taste receptors TAS1R2/TAS1R3 was evaluated. • Some structure/activity relationships were discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLYCOSIDES
*MASS spectrometry
*LEGUMES
*ACIDS
*TREES
Subjects
Details
- Language :
- English
- ISSN :
- 00319422
- Volume :
- 226
- Database :
- Academic Search Index
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 178942184
- Full Text :
- https://doi.org/10.1016/j.phytochem.2024.114204