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Benzylic rearrangement for urinary analysis of guanidino and ureido compounds in cardiac surgery–associated acute kidney injury using high‐performance liquid chromatography–tandem mass spectrometry.
- Source :
-
Rapid Communications in Mass Spectrometry: RCM . Sep2024, Vol. 38 Issue 17, p1-1572. 1572p. - Publication Year :
- 2024
-
Abstract
- This article presents a study on the use of urinary guanidino compounds (GCs) and ureido compounds (UCs) as biomarkers for cardiac surgery-associated acute kidney injury (CSA-AKI). The study utilized a benzylic rearrangement reaction and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to analyze the concentrations of GCs/UCs in urine samples from patients with CSA-AKI at different stages. The findings suggest that certain GC/UC metabolites show significant changes in concentration during CSA-AKI and could potentially serve as biomarkers for different stages of AKI. This research provides valuable resources and new therapeutic targets for further study on CSA-AKI. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 09514198
- Volume :
- 38
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Rapid Communications in Mass Spectrometry: RCM
- Publication Type :
- Academic Journal
- Accession number :
- 178973303
- Full Text :
- https://doi.org/10.1002/rcm.9853