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Regulation of cell function and identity by cellular senescence.

Authors :
Huna, Anda
Massemin, Amélie
Makulyte, Gabriela
Flaman, Jean-Michel
Martin, Nadine
Bernard, David
Source :
Journal of Cell Biology. 8/5/2024, Vol. 223 Issue 8, p1-9. 9p.
Publication Year :
2024

Abstract

During aging and in some contexts, like embryonic development, wound healing, and diseases such as cancer, senescent cells accumulate and play a key role in different pathophysiological functions. A long-held belief was that cellular senescence decreased normal cell functions, given the loss of proliferation of senescent cells. This view radically changed following the discovery of the senescence-associated secretory phenotype (SASP), factors released by senescent cells into their microenvironment. There is now accumulating evidence that cellular senescence also promotes gain-of-function effects by establishing, reinforcing, or changing cell identity, which can have a beneficial or deleterious impact on pathophysiology. These effects may involve both proliferation arrest and autocrine SASP production, although they largely remain to be defined. Here, we provide a historical overview of the first studies on senescence and an insight into emerging trends regarding the effects of senescence on cell identity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00219525
Volume :
223
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Cell Biology
Publication Type :
Academic Journal
Accession number :
178982175
Full Text :
https://doi.org/10.1083/jcb.202401112