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Prominent Expression of COL2A1, ACAN and IHH Genes are Observed in the Differentiation of Human Hematopoietic Stem Cells into Articular Type of Chondrocytes.

Authors :
Samundeshwari, Echambadi Loganathan
kattaru, Surekha
Kodavala, Sireesha
Chandrasekhar, Chodimella
Sarma, Potukuchi Venkata Gurunadha Krishna
Source :
Stem Cell Reviews & Reports. Jul2024, Vol. 20 Issue 5, p1370-1373. 4p.
Publication Year :
2024

Abstract

This document summarizes a research study conducted in India on the differentiation of human hematopoietic stem cells (HSCs) into articular chondrocytes, the main cells in articular cartilage. The study found that HSCs can transform into chondrocytes when stimulated by external signals and identified specific genes involved in this process. The researchers also explored the role of different components in the differentiation medium in promoting chondrogenesis. The study suggests that HSCs have potential for regenerating injured articular cartilage. The document includes tables with details of the research methods and acknowledgements for the support and facilities provided by the institute. It also mentions the funding source and information about ethical approval and conflicts of interest. [Extracted from the article]

Details

Language :
English
ISSN :
15508943
Volume :
20
Issue :
5
Database :
Academic Search Index
Journal :
Stem Cell Reviews & Reports
Publication Type :
Academic Journal
Accession number :
178996085
Full Text :
https://doi.org/10.1007/s12015-023-10665-4