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Çöven Ekstraktı, Tahin, Saponin ve Sesaminin Tip 2 Diyabetik Farelerde Bazı Biyokimyasal Parametreler Üzerine Etkisi.
- Source :
-
Van Veterinary Journal . Jul2024, Vol. 35 Issue 2, p120-124. 5p. - Publication Year :
- 2024
-
Abstract
- The study aims to determine the effects of sesamin, saponin, sesamin+saponin, tahini, gypsophila extract and tahini+gypsophila extract on aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine levels in experimentally induced type 2 diabetes (T2DM) in mice. 92 Swiss albino male mice were used. After 8 mice were separated as healthy control (HC) group, T2DM was induced by high-fat feeding and streptozotocin (STZ) application. 84 T2DM mice were divided into 7 groups; diabetes control (DC), sesamin (D+SS), saponin (D+SP), sesamin+saponin (D+SS+SP), tahini (D+T), gypsophila extract (D+C) and tahini+gypsophila extract (D+T+C) were applied for 2 weeks. At the end of the research, the animals were euthanized and serum was obtained. Serum AST, ALT, BUN and creatinine levels were measured on an autoanalyzer. AST level was higher than D+SP group (p<0.05), but like D+SP, D+T and DC groups (p>0.05). The AST level of the HC group was lower than DC, D+SP, D+SS+SP and D+T groups (p<0.05). While the ALT levels of DC and D+SP groups were similar to others (p>0.05), they were different from the other groups (p<0.05). While the BUN values of HC and DC groups were similar (p>0.05), BUN values of the two groups were different from the other groups (p<0.05). While the creatinine levels of HC, DC, D+SP and D+T groups were like each other (p>0.05), they were different from the other groups (p<0.05). As a result, it can be stated that the applied substances may have positive effects on T2DM liver and kidney function. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Turkish
- ISSN :
- 21493359
- Volume :
- 35
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Van Veterinary Journal
- Publication Type :
- Academic Journal
- Accession number :
- 179004592
- Full Text :
- https://doi.org/10.36483/vanvetj.1481278