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Primary Vitreoretinal Lymphoma Presenting Solely with Asymptomatic Peripheral Drusenoid Lesions.

Authors :
Lu, Brianna
Wong, Jovi C.Y.
Kritzinger, Justin
Wong, David T.
Source :
Case Reports in Ophthalmology. Aug2024, Vol. 15 Issue 1, p607-613. 7p. 2 Illustrations.
Publication Year :
2024

Abstract

<bold><italic>Introduction:</italic></bold> Primary vitreoretinal lymphoma (PVRL) is a rare malignant tumor that typically involves the retina, vitreous, or optic nerve head. PVRL often occurs concurrently with central nervous system lymphoma. Here, we present the first report of a patient with biopsy-confirmed PVRL presenting solely with asymptomatic peripheral drusenoid lesions. <bold><italic>Case Presentation:</italic></bold> A woman in her 70s presented with new elevated amelanotic yellow lesions with overlying pigment in both of her eyes not previously seen prior to cataract surgery. Over the next 4 months, there was waxing and waning of lesions which resolved and first appeared in the right eye and then the left. A diagnostic vitrectomy of the left eye revealed B-cell lymphoma. The patient elected for initial treatment with radiation therapy of both orbits. A new lesion was identified in her right eye nearly 18 months after starting maintenance therapy with ibrutinib, following which systemic chemotherapy with methotrexate was initiated. <bold><italic>Conclusion:</italic></bold> Elevated clinical suspicion for a malignant process is needed for patients with progressive new retinal lesions in older age. Local radiation therapy to the orbits alone may not be sufficient to prevent progression despite initial presentation showing confinement of disease to the intraocular space. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16632699
Volume :
15
Issue :
1
Database :
Academic Search Index
Journal :
Case Reports in Ophthalmology
Publication Type :
Academic Journal
Accession number :
179017750
Full Text :
https://doi.org/10.1159/000540051