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Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes.

Authors :
Marques da Silva, Marllyn
Santana Moura, Yanara Alessandra
Leite, Arthur Hipólito Pereira
Souza, Kerolayne Lira Da Silva
Brandão Costa, Romero Marcos Pedrosa
Nascimento, Thiago Pajeú
Porto, Ana Lúcia Figueiredo
Bezerra, Raquel Pedrosa
Source :
Drug & Chemical Toxicology. Aug2024, p1-11. 11p. 2 Illustrations.
Publication Year :
2024

Abstract

Abstract\nHIGHLIGHTSCardiovascular diseases (CVDs) cause 30% of deaths each year, and in 2030, around 23.6 million people will die due to CVDs. The major challenge is to obtain molecules with minimal adverse reactions that can prevent and dissolve blood clots. In this context, fibrinolytic enzymes from diverse microorganism sources have been extensively investigated due to their potential to act directly and specifically on the fibrin clot, preventing side effects and performing potential thrombolytic effects. However, most researches focus on the purification and characterization of proteases, with little emphasis on the mechanism of action and pharmacological characteristics, including toxicity assays which are essential to assess safety and side effects. Therefore, this work aims to emphasize the importance of evaluations indicating the toxicological profile of fibrinolytic proteases through in vitro and in vivo tests. Both types of assays contribute as preclinical stage in drug development and are crucial for clinical applications. This scarcity creates arbitrary barriers to further studies. This work should further encourage the development of studies to ensure the safety and effectivity of fibrinolytic proteases.Suggested pre-clinical trials aim to validate more specific methods for fibrinolytic enzymes;Current toxicity standards can be adapted to better assess the profile of fibrinolytic enzymes;The class of fibrinolytic enzymes must be carefully evaluated according to the method of application.Suggested pre-clinical trials aim to validate more specific methods for fibrinolytic enzymes;Current toxicity standards can be adapted to better assess the profile of fibrinolytic enzymes;The class of fibrinolytic enzymes must be carefully evaluated according to the method of application. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01480545
Database :
Academic Search Index
Journal :
Drug & Chemical Toxicology
Publication Type :
Academic Journal
Accession number :
179080827
Full Text :
https://doi.org/10.1080/01480545.2024.2367561