Back to Search Start Over

Association Between Social Vulnerability and Streptococcus pneumoniae Antimicrobial Resistance in US Adults.

Authors :
Mohanty, Salini
Ye, Gang
Sheets, Charles
Cossrow, Nicole
Yu, Kalvin C
White, Meghan
Klinker, Kenneth P
Gupta, Vikas
Source :
Clinical Infectious Diseases. 8/15/2024, Vol. 79 Issue 2, p305-311. 7p.
Publication Year :
2024

Abstract

Background Growing evidence indicates antimicrobial resistance disproportionately affects individuals living in socially vulnerable areas. This study evaluated the association between the CDC/ATSDR Social Vulnerability Index (SVI) and Streptococcus pneumoniae (SP) antimicrobial resistance (AMR) in the United States. Methods Adult patients ≥18 years with 30-day nonduplicate SP isolates from ambulatory/hospital settings from January 2011 to December 2022 with zip codes of residence were evaluated across 177 facilities in the BD Insights Research Database. Isolates were identified as SP AMR if they were non-susceptible to ≥1 antibiotic class (macrolide, tetracycline, extended-spectrum cephalosporins, or penicillin). Associations between SP AMR and SVI score (overall and themes) were evaluated using generalized estimating equations with repeated measurements within county to account for within-cluster correlations. Results Of 8008 unique SP isolates from 574 US counties across 39 states, the overall proportion of AMR was 49.9%. A significant association between socioeconomic status (SES) theme and SP AMR was detected with higher SES theme SVI score (indicating greater social vulnerability) associated with greater risk of AMR. On average, a decile increase of SES, indicating greater vulnerability, was associated with a 1.28% increased risk of AMR (95% confidence interval [CI],.61%, 1.95%; P =.0002). A decile increase of household characteristic score was associated with a 0.81% increased risk in SP AMR (95% CI,.13%, 1.49%; P =.0197). There was no association between racial/ethnic minority status, housing type and transportation theme, or overall SVI score and SP AMR. Conclusions SES and household characteristics were the SVI themes most associated with SP AMR. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10584838
Volume :
79
Issue :
2
Database :
Academic Search Index
Journal :
Clinical Infectious Diseases
Publication Type :
Academic Journal
Accession number :
179092199
Full Text :
https://doi.org/10.1093/cid/ciae138