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Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase.
- Source :
-
Advanced Synthesis & Catalysis . 8/6/2024, Vol. 366 Issue 15, p3290-3296. 7p. - Publication Year :
- 2024
-
Abstract
- Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi‐enzymatic sequence that allows to obtain vic‐halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPASES
*KINETIC resolution
*ENANTIOMERIC purity
*ALKENES
*HALOGENATION
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 366
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 179110360
- Full Text :
- https://doi.org/10.1002/adsc.202400516