Synthesis of new resin containing imidazole as a dental composite based on silk powder and evaluation of its anti-cancer and antibacterial activity.

In the present study, a composite composed of resin containing imidazole-GMA resin and a natural filler of silk powder (IGMSP) was used as an alternative to bisphenol A-glycidyl methacrylate (Bis-GMA) dental composites. Dental composite was prepared by both optical and thermal polymerizations. FTIR, 1HNMR spectroscopy, and FESEM-EDX were used to identify the structure and morphology of the synthesized compounds. Thereafter, the thermal properties, water sorption and solubility, and anti-cancer and antibacterial activities of the composite were investigated. The structure of Imidazole-GMA resin as well as the successful surface modification of the filler with Si–O groups were confirmed with 1HNMR and FTIR spectra. Due to the use of natural filler of silk powder, the thermal resistance of the composite was found to be relatively low. The water adsorption and solubility of composite were lower than Bis-GMA. The results of antibacterial properties and cytotoxicity of the composite were much promising due to the presence of imidazole components in the resin structure. This composite was shown to have a significant inhibitory effect on MCF7 cells (IC50 = 11.4 µM, Maximum inhibitory effect 94.68%), and it was proved that Imidazole-GMA has significant effects on all three gram-negative (IZD 27–35 mm) and three gram-positive (IZD 22–29 mm) bacterial species. [ABSTRACT FROM AUTHOR]