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Synthesis of tetralone and indanone derivatives via cascade reductive Friedel–Crafts alkylation/cyclization of keto acids/esters.
- Source :
-
Chemical Communications . 9/7/2024, Vol. 60 Issue 69, p9274-9277. 4p. - Publication Year :
- 2024
-
Abstract
- We disclose herein a metal-free cascade reductive Friedel–Crafts alkylation/cyclization of keto acids/esters for the synthesis of tetralones and indanones. Owing to the simple reaction conditions and setup, this protocol features broad substrate generality, facile scalability, and remarkable functional group tolerance, including the synthesis of bioactive molecule sertraline. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KETONIC acids
*ALKYLATION
*ESTERS
*RING formation (Chemistry)
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 69
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 179176776
- Full Text :
- https://doi.org/10.1039/d4cc02754j