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Prähospitale Analgesie mit Nalbuphin und Paracetamol im Vergleich zu Piritramid durch Notfallsanitäter*innen – eine multizentrische Observationsstudie.
- Source :
-
Die Anaesthesiologie . Sep2024, Vol. 73 Issue 9, p583-590. 8p. - Publication Year :
- 2024
-
Abstract
- Objective: Following recent changes to the German Narcotics Act, this article examines prehospital analgesia by paramedics using piritramide vs. nalbuphine + paracetamol. Material and methods: Prehospital analgesia administered by paramedics from the Fulda (piritramide) and Gütersloh (nalbuphine + paracetamol) emergency services was compared regarding pain intensity at the beginning and end of the mission, measured using the numeric rating scale (NRS). Additionally, an analysis of the resulting complications was carried out. Results: In this study 2429 administrations of analgesia were evaluated (nalbuphine + paracetamol: 1635, 67.3%, initial NRS: 8.0 ± 1.4, end of NRS: 3.7 ± 2.0; piritramide: 794, 32.7%, initial NRS: 8.5 ± 1.1, end of NRS: 4.5 ± 1.6). Factors influencing NRS change were initial NRS (regression coefficient, RC: 0.7075, 95% confidence interval, CI: 0.6503–0.7647, p < 0.001), treatment with nalbuphine + paracetamol (RC: 0.6048, 95% CI: 0.4396–0.7700, p < 0.001). Treatment with nalbuphine + paracetamol (n = 796 (48.7%)) compared to piritramide (n = 190 (23.9%)) increased the odds of achieving NRS < 4 (odds ratio, OR: 2.712, 95% CI: 2.227–3.303, p < 0.001). Complications occurred in n = 44 (5.5%) with piritramide and in n = 35 (2.1%) with nalbuphine + paracetamol. Risk factors for complications were analgesia with piritramide (OR: 2.699, 95% CI: 1.693–4.301, p < 0.001), female sex (OR: 2.372, 95% CI: 1.396–4.029, p = 0.0014), and age (OR: 1.013, 95% CI: 1.002–1.025, p = 0.0232). Conclusion: Compared with piritramide, prehospital analgesia with nalbuphine + paracetamol has favorable effects in terms of analgesic efficacy and complication rates and should therefore be considered in future recommendations for paramedics. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PAIN measurement
*NALBUPHINE
*CRONBACH'S alpha
*PIPERIDINE
*EMERGENCY medical technicians
*SCIENTIFIC observation
*EMERGENCY physicians
*EMERGENCY medicine
*EMERGENCY medical services
*DESCRIPTIVE statistics
*ANALGESIA
*ODDS ratio
*RESEARCH
*AMBULANCES
*DRUG efficacy
*COMPARATIVE studies
*CONFIDENCE intervals
*ACETAMINOPHEN
*PSYCHOSOCIAL factors
*REGRESSION analysis
Subjects
Details
- Language :
- German
- ISSN :
- 27316858
- Volume :
- 73
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Die Anaesthesiologie
- Publication Type :
- Academic Journal
- Accession number :
- 179295670
- Full Text :
- https://doi.org/10.1007/s00101-024-01449-7