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Selective C—H deuterium exchange in the oxacamphanyl moiety linked to the carbamide group.

Selective C—H deuterium exchange in the oxacamphanyl moiety linked to the carbamide group.

Authors :
Nichugovskiy, A. I.
Eshtukova-Shcheglova, E. A.
Fayzullin, R. R.
Kuznetsov, D. V.
Burmistrov, V. V.
Novakov, I. A.
Source :
Russian Chemical Bulletin. Jul2024, Vol. 73 Issue 7, p1936-1943. 8p.
Publication Year :
2024

Abstract

In the 1H NMR spectra (DMSO-d6) of 1,3-disubstituted ureas containing the 4,7,7-trimethyl-3-oxo-4-oxabicyclo[2.2.1]heptan-1-yl substituent, the signals for the CH2—CH2 moiety appear as an ADMP-type spin system consisting of four doublets of doublets of doublets with chemical shifts in the range from 1.54 to 2.80 ppm. The experiment in CD3OD showed the disappearance of the signal at δ 2.80 and a change in the multiplicity of the other signals, which is indicative of the selective deuterium exchange of one of the four protons of the CH2—CH2 group for a deuterium atom. This allows the selective modification of compounds containing the oxacamphanyl moiety. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10665285
Volume :
73
Issue :
7
Database :
Academic Search Index
Journal :
Russian Chemical Bulletin
Publication Type :
Academic Journal
Accession number :
179358380
Full Text :
https://doi.org/10.1007/s11172-024-4312-9