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The need to diversify genomic studies: Insights from Andean highlanders and Amazonians.

Authors :
Alvim, Isabela
Silva-Carvalho, Carolina
Mendes de Aquino, Marla
Borda, Victor
Sanchez, Cesar
Padilla, Carlos
Cáceres, Omar
Rezende-Diniz, Isabela
Saraiva-Duarte, Julia
Faria-Costa, Lucas
Santolalla, Meddly L.
Rodrigues-Soares, Fernanda
Zolini, Camila
Llerena, Adrián
O'Connor, Timothy D.
Gilman, Robert H.
Guio, Heinner
Tarazona-Santos, Eduardo
Source :
Cell. Sep2024, Vol. 187 Issue 18, p4819-4823. 5p.
Publication Year :
2024

Abstract

More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response in Andean highlanders and Amazonians, considering their environment, history, genetic structure, and historical biases in the perception of biological diversity of Native Americans. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00928674
Volume :
187
Issue :
18
Database :
Academic Search Index
Journal :
Cell
Publication Type :
Academic Journal
Accession number :
179364834
Full Text :
https://doi.org/10.1016/j.cell.2024.07.009