SphK/S1P 在心血管疾病中的作用.

Sphingosine-1-phosphate (SIP) is a highly active membrane phospholipid metabolite with important physiological roles in the cardiovascular system. Sphingosine kinase (SphK) is a lipase that is important for maintaining stable SIP levels in vivo. S1P exerts different physiological effects in cardiovascular diseases by catalytically regulating the binding of SIP to G protein-coupled receptors (SIPR1-5) on the cell surface, thus exerting different physiological effects in cardiovascular diseases. For example, they are involved in regulating the development of diseases such as atherosclerosis, myocardial ischemia-reperfusion injury, myocardial infarction, heart failure and other diseases, maintaining the barrier function of vascular endothelial cells, protecting the endothelial glycocalyx layer, leukocyte adhesion, inflammatory reactions and other pathophysiologic processes. [ABSTRACT FROM AUTHOR]