PD-1/PD-L1 信号通路在脓毒症不同器官免疫调控中的研究进展.

Sepsis is a life-threatening organ dysfunction caused by the imbalance of host immune response to infection, which immune regulation mechanism is complex and has not been clarified. Programmed death receptor-1 （PD-1）/programmed death receptor ligand-1 （PD-L1） is a negative co-inhibitory molecule that has attracted much attention in recent years. Studies have shown that PD-1/PD-L1 signaling pathway plays an important immunosuppressive role in sepsis. There are differences in immune regulation mechanisms in heart, liver, spleen, lung and kidney, which has not been clarified. Immune regulation of PD-1/PD-L1 in different organs of sepsis is reviewied in this article, which could to provide a new direction for the study of sepsis. [ABSTRACT FROM AUTHOR]