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Cold temperature-induced modifications to the composition and structure of the lipopolysaccharide of Yersinia pestis
- Source :
-
Carbohydrate Research . Jul2005, Vol. 340 Issue 9, p1625-1630. 6p. - Publication Year :
- 2005
-
Abstract
- Abstract: Following a report of variations in the lipopolysaccharide (LPS) structure of Yersinia pestis at mammalian (37°C) and flea (25°C) temperatures, a number of changes to the LPS structure were observed when the bacterium was cultivated at a temperature of winter-hibernating rodents (6°C). In addition to one of the known Y. pestis LPS types, LPS of a new type was isolated from Y. pestis KM218 grown at 6°C. The core of the latter differs in: (i) replacement of terminal galactose with terminal d-glycero-d-manno-heptose; (ii) phosphorylation of terminal oct-2-ulosonic acid with phosphoethanolamine; (iii) a lower content of GlcNAc, and; (iv) the absence of glycine; lipid A differs in the lack of any 4-amino-4-deoxyarabinose and presumably partial (di)oxygenation of a fatty acid(s). The data obtained suggest that cold temperature switches on an alternative mechanism of control of the synthesis of Y. pestis LPS. [Copyright &y& Elsevier]
- Subjects :
- *SACCHARIDES
*ENTEROBACTERIACEAE
*YERSINIA pestis
*PHOSPHORYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 00086215
- Volume :
- 340
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Research
- Publication Type :
- Academic Journal
- Accession number :
- 17948281
- Full Text :
- https://doi.org/10.1016/j.carres.2005.04.007