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Synthesis of new 4, 5-disubstituted-6-methyl-2-(methylthio) pyrimidines via C-C coupling reactions.
Synthesis of new 4, 5-disubstituted-6-methyl-2-(methylthio) pyrimidines via C-C coupling reactions.
- Source :
-
Journal of Sulfur Chemistry . Oct2024, Vol. 45 Issue 5, p690-702. 13p. - Publication Year :
- 2024
-
Abstract
- A convenient synthetic protocol for diverse 4, 5-disubstituted-6-methyl-2-(methylthio)pyrimidines was successfully developed by Sonogashira reactions. In the presence of Pd-Cu catalysts, one-pot, multi-step reaction of amines, terminal alkynes, and 4-chloro-5-iodo-6-methyl-2-(methylthio)pyrimidine in DMF at 80°C resulted in 4, 5-disubstituted-6-methyl-2-(methylthio)pyrimidine derivatives in moderate to good yields. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17415993
- Volume :
- 45
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Sulfur Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 179483534
- Full Text :
- https://doi.org/10.1080/17415993.2024.2390541