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Synthesis of new 4, 5-disubstituted-6-methyl-2-(methylthio) pyrimidines via C-C coupling reactions.

Synthesis of new 4, 5-disubstituted-6-methyl-2-(methylthio) pyrimidines via C-C coupling reactions.

Authors :
Cheldavi, Forough
Bakherad, Mohammad
Keivanloo, Ali
Rezaeifard, Amin
Nikpour, Mohsen
Source :
Journal of Sulfur Chemistry. Oct2024, Vol. 45 Issue 5, p690-702. 13p.
Publication Year :
2024

Abstract

A convenient synthetic protocol for diverse 4, 5-disubstituted-6-methyl-2-(methylthio)pyrimidines was successfully developed by Sonogashira reactions. In the presence of Pd-Cu catalysts, one-pot, multi-step reaction of amines, terminal alkynes, and 4-chloro-5-iodo-6-methyl-2-(methylthio)pyrimidine in DMF at 80°C resulted in 4, 5-disubstituted-6-methyl-2-(methylthio)pyrimidine derivatives in moderate to good yields. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17415993
Volume :
45
Issue :
5
Database :
Academic Search Index
Journal :
Journal of Sulfur Chemistry
Publication Type :
Academic Journal
Accession number :
179483534
Full Text :
https://doi.org/10.1080/17415993.2024.2390541