Correlation of IgM seropositivity in dengue NS1Ag positive samples of patient from rural population.

Introduction: Dengue, also known as "break bone fever," is a viral infection transmitted by Aedes aegypti followed by Aedes albopictus. It is more prevalent in tropical and subtropical climates. While many individuals infected with dengue may not experience any symptoms, those who do may commonly exhibit high fever, headache, body aches, nausea, and rash. In severe cases, dengue can be fatal, with some individuals developing dengue haemorrhagic fever characterized by bleeding, low blood platelet levels, and blood plasma leakage, or dengue shock syndrome, which involves dangerously low blood pressure. Aim: To detect Dengue IgM with IgM capture ELISA in NS1 positive samples of patients attending a tertiary care hospital. Material and Methods: This study was conducted as a prospective cohort study, conducting within the study period June 2022 to December 2022 involving patients admitted to GBCM and Subharti hospital, Dehradun. A Comparative study to detect Dengue IgM with IgM capture ELISA in NS1 positive samples of patients attending a tertiary care hospital among 498 patients. Results: Among 258 female patients, 24 were NS1-positive, 36 were IgM-positive, and 46 were IgG-positive and in male patients (240), 59 were NS1 positive, 40 were IgM positive, and 39 were IgG positive. In July 2022, a higher correlation coefficient of 0.422029 (p-value: 0.000570) was observed, indicating a stronger association between NS1 antigen and IgM seropositivity. Thrombocytopenia with most cases showing platelet counts ranging from 50,000 to 100,000 platelets/cu mm. Conclusion: This study enhances our understanding of the correlation between IgM seropositivity and NS1 antigen positivity in dengue cases within rural populations. The findings have significant implications for early detection, diagnosis, and management of dengue infection, emphasizing the value of IgM as a diagnostic marker. [ABSTRACT FROM AUTHOR]