Clinicopathological correlation of duodenal biopsy in patients with malabsorption.

Background: Malabsorption syndrome affects millions of people in the world and is mostly associated with gastrointestinal (GI) symptoms like pain abdomen, bloating, flatulence, diarrhoea and some extra intestinal manifestations like iron deficiency anaemia, growth retardation, muscle cramps etc. The aetiology of malabsorption varies according to the age of the patient and geographical location. Aims and Objectives: To study morphological spectrum of duodenal biopsies in patients presenting with symptoms of malabsorption and to correlate the histopathological findings with endoscopic findings and relevant laboratory parameters where ever possible. Material and Methods: A retro prospective study was done for a period of 3 years and 6 months from January 2019 till October 2022. The study included75 presenting with signs and symptoms of malabsorption. Patients with history of major gastrointestinal surgery were excluded from the study. Result and Analysis: The patients had a mean age (32.8) years, with male: female ratio to be 04: 1, the most common presenting complaint was pain abdomen (72%) followed by anaemia under evaluation. (24%) The commonest diagnosis in the study was celiac disease (33. 3%). A good correlation was established with Endoscopic and laboratory findings as (45. 27%) cases showed abnormal findings and serological findings (Anti TTG levels) correlated well with celiac disease. Conclusion: Duodenal biopsy is a useful parameter in corroborating a diagnosis in patients presenting with symptoms of malabsorption. However, significant correlation of biopsy with endoscopic, serologic and hematologic parameters is of utmost importance to reach a final diagnosis. [ABSTRACT FROM AUTHOR]