Evaluation of anti-atherosclerotic activity of stem bark of Peltophorum pterocarpum by high fat diet induced atherosclerosis model in experimental animals.

Introduction: An ongoing inflammatory is condition in atherosclerosis in which there is fat streak, a buildup of foam cells with lipid content in the artery's intimal layer act as precursor to atherosclerosis. Peltophorum pterocarpum stem bark extract found to be effective in inhibition of platelet aggregation and possess anti-inflammatory effect that may be useful in treating atherosclerosis. Therefore, the goal of the current investigation is to ascertain if the ethanolic extract of Peltophorum pterocarpum stem bark (EEPP) has anti-atherosclerosis effect in Wistar rats using a high fat diet in atherosclerotic induced atherosclerosis model for 60 days. Atherosclerosis was induced in male Wistar rats by giving them a high-fat diet. Following induction, oral doses of EEPP (250, 500 mg/kg) and atorvastatin (10 mg/kg) were administered orally to the rats for the following 20 days. Methods: The literature was searched using PubMed and google scholar search Engines. A total 30 plants were mentioned through database searches. Papers from between 1999 and 2022 were included. An attempt was made to document relevant literature that is only focused on potential effect of various plants in treatment of atherosclerosis. Results: In comparison to the control group, EEPP was able to significantly lower the raised serum levels of total cholesterol, triglyceride, LDL, and VLDL while significantly increasing the levels of HDL. When compared to the diseased control group, EEPP significantly lessened damage to the endothelial lining of the aorta and had an impact on lumen size by lowering cholesterol buildup. [ABSTRACT FROM AUTHOR]